CALECIM Professional Q&A: Stem Cell Science and Skincare Patient Education

CALECIM® Professional has had a remarkable year to date. As our network grows and more people hear about the proven effects of our products, more patients are asking about CALECIM® Professional and what it can do for their skin. For our physician partners who want to provide quick information for interested patients, here are straightforward answers to the most common questions we get asked about CALECIM® Professional.

What makes CALECIM® Professional products different from the ones I already use?

The nutrients, collagen, and proteins in CALECIM® Professional are derived from neonatal mammalian stem cells, which signal skin restoration in a way our human skin cells can understand, and in a way, plant-derived ingredients cannot. The technology used to create CALECIM® products are the result of 10 years of cutting edge research by CellResearchCorp. CALECIM® also uses a unique trans-epidermal delivery system so its products are better absorbed by your skin.

Most growth factor skin care products in the market are made with skin cell-derived proteins. Skin cells do not stem cells, even though they may have been extracted from the fetal skin. Skin cells are already differentiated and do not have the same regenerative and proliferative abilities that stem cells have.

Are there stem cells in CALECIM® Professional products?

There are no stem cells in CALECIM® products. The stem cells are removed from a culture media which is then used in CALECIM® creams and serums. The ‘youth messages’ are already excreted by the stem cells in the media.

Laboratory testings reveal lots of natural ‘goodness’ that stem cells produce in the media: these include hyaluronic acid, fibronectin, soluble collagen, and the all-important peptides and glycoproteins, a unique mix of cellular signaling biochemical messages, that are specific and unique to stem cells.

What are the active ingredients in CALECIM®?

All CALECIM® Professional products have concentrated amounts of CALECIM® Conditioned Media, which is made up of stem cell-derived soluble collagen, albumin, fibronectin, hyaluronic acid, and consolidated peptides or glycoproteins. All of these elements work together to nourish and support skin structure and speed up cell renewal and proliferation for a more youthful appearance. Each CALECIM®Professional product also has added ingredients to boost specific benefits.

What sort of results can I expect and how soon will I see them?

In tests in the United States and Singapore, patients using CALECIM® Professional Multi-action Cream noticed lifting in the eye area and eyebrows, improved complexion, and improved appearance in areas such as the jawline and nasolabial folds. You should see the first improvements after two weeks of use, with optimal results after 90 days.

Are there any side-effects from using CALECIM® products?

There have not been any negative side effects reported from CALECIM® when it’s used properly. There’s a small chance that some skin blemishes may appear when the skin renewal process kicks in, as the skin will be shedding its old cells to turn over new cells.

What kind of products are available for purchase now?

Right now there are three products in CALECIM® Professional’s advanced skin care line. CALECIM®Professional Serum is intended for after in-clinic treatment soothing and healing, CALECIM® Multi-action Cream addresses significant signs of aging such as loss of facial definition and volume, laxity and decreased skin density.

CALECIM® Restorative Hydration Cream deeply hydrates skin from within with naturally derived hyaluronic acid. All these products have regenerative anti-ageing properties, speed up skin cell renewal and proliferation, and help restore skin to its optimal 28-day cycle.

When should I apply my CALECIM® Professional products?

CALECIM® Professional Serum should be applied after an in-clinic procedure, or after an at-home gentle exfoliation to allow better penetration. CALECIM® Professional Multi-action Cream should be used twice daily as an at-home maintenance skin regime, using a pearl-sized amount, after toner. CALECIM® Professional Restorative Hydration Cream should be used after cleansing and toning, and after application of Multi-Action Cream, in the mornings and evenings.

How long will my CALECIM® Professional products last?

A 50ml jar of CALECIM® Restorative Hydration Cream or CALECIM® Multi-action Cream should last around two months. CALECIM® Professional Serum is intended to be used within a few days after treatment.

Where can I buy CALECIM® Professional products?

CALECIM® Professional is sold exclusively through authorized physicians. If you check our physician directory you can see all the places where CALECIM® is currently available around the world.

Are you a doctor? A patient? Get in touch!


Plant Stem Cell Extracts vs CALECIM Conditioned Media: How They Interact with Our Skin

There are a few things scientists and clinicians want to see when measuring the success of a skin repair product. Among these are fast wound healing and healthy cell turnover. Skincare consumers look for different measures of success when choosing a skin care product. Those concerned with aging symptoms—such as wrinkles, thinning skin, and age spots—look for visible results in diminishing these signs of degeneration. The interesting thing is, the same repair and regenerative agents in our body that repair wounds are the same ones helping us maintain youthful skin.

These are our stem cells.

We come equipped, biologically, to self-heal and regenerate thanks to these stem cells. However, we know that as our ability to heal diminishes with age, so does our skin’s ability to regenerate, resulting in the loss of our youthful, healthy glow. Aged, thin skin with lines is as much a sign of the diminishing numbers of stem cells in our body, as a wound that does not heal as quickly.
The cosmeceutical industry is more than aware of the scientific miracle of stem cells on skin. This explains the proliferation of ‘stem cell skincare’ over the years; products that claim to be able to replicate the work that our own aged stem cells used to do. The term ‘stem cell’ has thus been used to describe the workings of their products, though many brands are far from delivering anything close to stem cell technology to consumers’ skin. The informed consumer knows to further investigate these claims.

Why has real stem cell technology in skincare been unavailable till now?

It would be hard to believe, from reading the marketing materials of skincare brochures, that stem cells are actually quite challenging to harvest. From the overuse of the term ‘stem cell technology’ to describe the action of skin hydration to sun protection, one would think that stem cells were abundant and freely available. The truth is: stem cells are rare, difficult to extract, and hard to purify.
Past sources of stem cells have produced such limited quantities that stem cell technology has only really been applied in scientific and medical therapies. The most common source of stem cells used in these therapies are from bone marrow which is usually derived from adult donors. It is a painful process of stem cell extraction with a low yield, which is why skincare applications using bone marrow stem cells are virtually non-existent.
Without a source of mammalian or human stem cells for research, many beauty and cosmeceutical brands have turned to plant stem cells and their derivatives to create skincare lines. There is a difference, however, in how plant cells interact with skin. The process is unlike the communicative synergies found between mammalian or human-derived stem cells and human skin.
Many CALECIM® patients wonder about the differences between plant stem cells and mammalian stem cells, as well as their skin-restoring abilities on our skin. Here, we offer a quick comparison of these two sources and the role they both play in maintaining healthy skin.

Stem Cell Differences and Similarities

It’s important to understand that plant stem cells are fundamentally different from the stem cells found in our bodies. Both stem cell types produce biochemicals called cytokines that ‘signal’ and communicate with our other cells, however, plant stem cell signals are directed at other cells of the plant, and have little if any effect on mammalian cells.
Likewise, between mammalian species, stem-cell derived cytokines and growth factors are easily recognized by other mammalian cells, but not by plant cells. Overall, although the amino acid building blocks to produce these proteins are the same, the eventual proteins produced have a different structural configuration which fundamentally changes the intercellular ‘language’ and thus the ability to communicate with each other.

Benefits of Botanical Stem Cell Products

There are many recognized botanical ingredients that are proven to be beneficial to our skin. Moisturizing ingredients, as well as vitamin extracts and plant oils have unique abilities to protect our skin from damage and dehydration.
CALECIM® also recognizes the value of botanical skin care ingredients. For example, you’ll find aloe vera in our CALECIM® Professional Restorative Hydration Cream. We’ve just married the best of both worlds!

Benefits of Mammalian Stem Cell Products

The great advantage of using products that have mammalian stem cell conditioned media is that our human skin cells are able to decipher and act on the biochemical signals they contain. Normally our own epithelial stem cells send signals to renew and heal our skin, however as we age their potency and activity diminishes. By using mammalian stem cell conditioned media we can give our skin a boost of supporting proteins and skin-restoring signals in the high doses our bodies are accustomed to from when we were younger.

New Source of Mammalian Stem Cells

CALECIM® Professional is able to deliver the promise of revolutionary stem cell technology in its skincare because of its unique source of stem cells. The cord lining was discovered to be a rich source of neonatal stem cells; a source that is so abundant that an effective skin care using real stem cell technology can finally be created because these young stem cells are plentiful, vigorous and are able to produce consistently quantities of high-quality growth factors and proteins that have fast-acting effects on skin. CALECIM® Professional is the first skincare line to offer skincare benefits using technology from cord lining stem cells.

Proven Results in CALECIM® Professional
For all skincare products, high-quality active ingredients should always be able to prove effective in in-vitro tests which can explain scientifically the visible results on skin. In laboratory trials of CALECIM®Professional products, we’ve measured the exact thickening of the dermis — a sign of restored cell vitality — with the application of CALECIM® Professional Serum. The results on a patient are firmer skin with a visible lifting effect. There is also in-vitro evidence that skin cells proliferate faster when exposed to CALECIM®. This means that skin turnover is accelerated, resulting in improved radiance and glow as new skin cells are revealed.

Noted dermatologists have also proven the ability of CALECIM® Professional Serum to reduce redness, pain, and discomfort after laser resurfacing in independent trials. These results are not news to our scientists who have already witnessed the rapid healing qualities of CALECIM® in laboratory tests.

Rooted in Real Stem Cell Science

CALECIM® Professional is wholly owned by CellResearchCorp, a biotech company based in Singapore that discovered an ethical process for extracting an abundant source of mammalian stem cells from the umbilical cord lining membrane (post birth). This discovery led CellResearchCorp. to develop and launch the CALECIM® Professional skincare line, with products containing high concentrations of powerful stem cell conditioned media. This process has been patented in 41 territories around the world. Only CALECIM® Professional is licensed to use this technology for skin care applications.
CellResearchCorp is currently undergoing USFDA trials for its technology to be used in chronic diabetic wounds. Cord lining stem cells, the company’s proprietary source of stem cells, are also in clinical trials within scientific collaborations around the world for the treatment of heart, cornea, brain, and liver diseases.
To learn more about the stem cells used to create the formula for CALECIM® Professional, please visit the website of our parent company, CellResearchCorp.

Bio-Signals and Youthful Skin: Growth Factors Explained

Like their wisest patients, dermatologists know better than to take note of every new trend to hit the market. That is, unless there are exceptional, proven benefits they can recreate in their clinics. Today, we’re all about addressing the microscopic, yet almighty growth factor because it is a key component to the success of our skincare line. So, how does the science of bio-signals impact our ability to “de-age” the skin?

Here, we take a brief overview of growth factors: where they come from, what they do, and why they represent an exciting new frontier in skin care for patients and physicians.

What are Cytokines and Growth Factors?

In order to understand where cytokines and growth factors come from, we need to take a closer look at stem cells and how they carry out their functions.

Most of us know stem cells can differentiate to build new cells and tissue, but another role of stem cells is to orchestrate the action of other cells in the body, including the body’s natural healing and regeneration response.
To carry out these actions, stem cells communicate by producing and releasing proteins called cytokines and growth factors. Controlled release of these cytokines and growth factors by stem cells will activate the biochemical pathways in adjacent cells and therefore command and control essential processes in the body.

All cytokines and growth factors bind to specific receptors on cell membranes, stimulating the cells to carry out a precise and intricate response, thus giving the cell its ‘directions’.

The types of cytokines and growth factors number in the thousands, each with its specific action. For skin renewal, these would include Epidermal Growth Factor (EGF), Vascular Endothelial Growth Factor (VEGF) and Transforming Growth Factor (TGF) amongst others.

It’s important to note that no single growth factor determines the outcome within the cells. It’s the unique mix of peptides in specific proportions designed by nature that triggers our skin to repair and grow.

The Role of Growth Factors in Aging

When we are young, we have a high ratio of robust stem cells in our bodies, and they secrete potent cytokines that allow rapid healing and renewal processes within our skin. As we age, our stem cell count and activity diminishes. As a result, our skin cells receive less cytokine and growth factor input, gradually losing its ability to effectively renew and repair itself.

Our skin’s reduced ability to heal—from wounds and also from environmental and sun damage — results in hyperpigmentation, wrinkles, sagging, and other signs of aging skin. CALECIM®’s solution to this is to re-engage the skin’s natural healing ability by replenishing lost cytokines and growth factors through topical products. This creates the perfect medium for healthy skin regeneration, revealing a new layer of fresh, supple skin that acts young again.

Although other cells such as fibroblasts and keratinocytes also secrete growth factors, stem cell growth factors are unique because they encourage cell repair and rejuvenation much more actively than cytokines secreted by cells that are not stem cells. Many skin care products currently in the market use growth factors that are derived from skin cells, not stem cells.

CALECIM® offers something unique: Products with a high concentration of cytokines and growth factors secreted from robust, neonatal stem cells

Replenishing Cytokines and Growth Factors with CALECIM® Professional

Although they have tremendous potential for advanced skin care, cytokines and growth factors are not common ingredients in skin care products, particularly those that you can purchase without a doctor’s prescription. The reason for this is that in the past it’s been difficult to find an ethical source of stem cells abundant enough to produce a consistent high quantity of cytokines and growth factors. Making skin care with sufficient quantities of cytokines and growth factors, therefore, became cost prohibitive.

In 2004, CellResearchCorp—CALECIM®’s parent company—patented the discovery and isolation of epithelial and mesenchymal stem cells from the umbilical cord lining membrane. Through this technology, CALECIM® has access to an abundant, ethical source of stem cells reliably producing cytokines and growth factors. The stem cells are cultivated in culture media in the lab and then removed from the media, leaving behind the cytokines, growth factors and other proteins they’ve secreted. This conditioned medium is the key active ingredient in CALECIM® Professional products.

Although there is still a long way to go in understanding cytokines and growth factors, initial studies and clinical trials done by CALECIM® have proven the tremendous value of these bio-signals, especially in speeding up post-laser skin rejuvenation healing and stimulating new skin cell growth. For more about the science behind CALECIM® Professional, visit our parent company CellResearchCorp., or speak to one of our authorized physician partners.


CellResearch Corporation: Patented Stem Cell Science

The story of CALECIM® Cosmeceuticals traces back to science and a specific discovery that is so revolutionary to stem cell science, it’s been patented in 41 territories globally. Given their potential for medical therapy, it’s no wonder that stem cells are being researched intensively around the world. CellResearch Corporation, the parent company of ground-breaking skincare line CALECIM® Professional, is one of those leading global research in stem cell science.

About CellResearch Corporation

Biotech company CellResearchCorp. was founded by three partners with an interest in cell biology. Based in Singapore, CellResearch Corp. focused its research on the umbilical cord lining. This cord lining is one of the richest known sources of neonatal cells, which hold far more powerful properties than adult stem cells. In 2004, CellResearchCorp.’s scientists discovered a way to isolate epithelial and mesenchymal stem cells from the umbilical cord lining membrane. The company immediately put this discovery up for intellectual property protection.

Our Patented Technology

CellResearchCorp. was granted patents that cover the concept of obtaining stem cells from mammalian umbilical cord lining and specifically the techniques of isolating and cultivating epithelial and mesenchymal stem cells. The company also secured patents that encompass all applications using umbilical cord lining stem cells, including therapeutic applications.

With these patents in hand, no other manufacturers can use CellResearchCorp.’s stem cell technology for any skin care or therapeutic applications. As a result, the products and therapies developed by CellResearch Corp. stand alone, both in the medical arena and in the field of skin care.

Patent Scope and Coverage

CellResearchCorp. holds patents for umbilical cord lining stem cell technology and the products derived therefrom in 41 territories across the world, including The United States, as well as in Europe, China, The United Kingdom, Singapore, Malaysia, Japan, Taiwan, and South Korea.

Applying Our Knowledge to Skincare

Right from the beginning, CellResearchCorp. has directed its patented stem cell knowledge toward the treatment of skin, specifically wounds and other related diseases, partnering with hospitals, universities, and doctors along the way. Now, the founders of CellResearch Corp. are channeling more than a decade of stem cell expertise into advanced cosmetic skin care under the CALECIM®Professional line—a true first for the beauty industry.

All CALECIM®Professional products contain CALECIM® Conditioned Media, a protein-rich formula of nutrients extracted from cord lining stem cells. Carefully created in CellResearchCorp.’s Singapore labs, this formula allows the renewal properties from umbilical cord extract to rejuvenate the skin. The powerful active ingredients in CALECIM® Conditioned Media stimulate the skin to act and look younger, restoring its natural texture, firmness, and elasticity.

So far CALECIM® Professional has launched three skin care products, CALECIM®  Professional Serum, CALECIM® Professional Multi-Action Cream, and CALECIM® Professional Restorative Hydration Cream. These products are only available from physicians in CALECIM®’s markets, with new countries being added all the time. To find CALECIM® near you, please visit our Physician Directory.

If you’d like to join our exclusive physician-dispensed network, please connect with us on CALECIM® Connect.


Skincare Science: The Benefits of Neonatal vs. Adult Stem Cells

Whether we’re talking about wound healing, treating chronic illness, or advancing anti-aging skin care—stem cell research holds the key to the future. CellResearchCorp. has discovered and patented an ethical, abundant source of stem cells drawn from mammalian umbilical cord lining membrane. This discovery represents a breakthrough in advanced skin care.
While most stem cell-derived products on the market use adult stem cells or plant stem cells, CellResearchCorp. draws from neonatal mammalian stem cells to formulate CALECIM® Professional serums and creams. These youthful cells are the reason CALECIM® skin care produces such visible results so quickly.
Here’s a closer look at how neonatal and adult stem cells compare in a cosmetic context:

Isolation and Cultivation

CellResearchCorp. holds patents in 41 territories worldwide for a technique that easily isolates mesenchymal stem cells (MSC) and epithelial stem cells (EpSC) from the umbilical cord lining membrane. Once isolated, neonatal cells are known to grow easily in culture. In contrast, adult stem cells, while found in many tissues and organs of the body, are hard to isolate; and once isolated are difficult to cultivate in the lab.

Stem Cell Yield

To develop its effective conditioned media, CALECIM® needs access to a bountiful source of stem cells. As we age, the population of stem cells in our body decreases, making it difficult to harvest a high number of cells. For example, the ratio of MSC to differentiate cells in bone marrow at birth is one in 10,000. By 30 years of age, that number drops to one in 250,000; and by 50 it’s one in 400,000.
Contrast those figures to the 20 million MSC explanted per square centimeter of cord lining membrane, and you’ll understand how this extremely high yield of stem cells enables CALECIM® to formulate products with a high quality active conditioned media. In fact, CellResearchCorp’s technology holds the potential to harvest an incredible 6,000,000,000 MSC from a single umbilical cord in one generation. In fact, Cord Lining Stem Cells can divide for 30 generations without a change in the viability of the stem cells. The umbilical cord lining also contains epithelial stem cells in equally abundant numbers which are crucial for maintaining the health of the epidermis.

Stem Cell Activity and Potency

As we age, not only does the absolute number of stem cells in our bodies decrease, but a number of protein signals in the form of cytokines and growth factors is also diminished. Agi, therefore, e reduces the effectiveness of MSC in our bodies.

Youthful neonatal stem cells, on the other hand, are remarkably robust and active, and the biochemical signals they secrete and send to other cells—directing them to repair and regenerate — are equally robust and potent.

Other Factors:

The harvesting of neonatal umbilical cord lining stem cells patented and conducted by CellResearchCorp. is non-invasive as the cord lining comes from afterbirth delivered after the birth of a newborn. It is thus a painless process with no adverse effects to the donor. Both epithelial and mesenchymal stem cells are available from the same source, so both epidermal and dermal layers of skin are addressed by CALECIM® products derived from these stem cells.

Taken together, we see why neonatal stem cells used in CALECIM® Professional products compare favorably with adult stem cell-derived alternatives. However, the proof, as they say, is in the pudding. The best way to experience the difference is to visit one of our partner physicians and discover CALECIM® for yourself.

Introducing CALECIM® Restorative Hydration Cream

February 2017, CALECIM® Professional celebrated the launch of the Restorative Hydration Cream worldwide. Delivering powerful ingredients from CALECIM®’s rejuvenating conditioned media through the skin via patented trans-epidermal delivery technology, the new CALECIM® Professional Restorative Hydration Cream is a breakthrough, anti-aging moisturizer unlike any other.

What’s the secret behind CALECIM®’s Restorative Hydration Cream?

The most active ingredients in the Restorative Hydration Cream are powerfully charged skin-restoring proteins from CALECIM® Cord Lining Conditioned Media, a product of more than 10 years of stem cell technology research. Customers and physicians will be pleased to know CALECIM® Professional Restorative Hydration Cream has a high 30% concentration of conditioned media and is enriched with naturally occurring hyaluronic acid.

This conditioned media and hyaluronic acid, as well as skin-supporting collagen, fibronectin, and albumin, are effectively delivered into skin via peptides or glycoproteins in the conditioned media. The cream also contains glyceryl stearate &emdash; a natural derived fatty acid that forms a non-oily barrier for skin &emdash; tocopherol (Vitamin E) for protection from free radicals, and aloe vera for antioxidant and anti-inflammatory properties.

Of course, if it’s going to work, this breakthrough formula needs a breakthrough delivery system. CALECIM® has patented its delivery technology, which allows active ingredients to be fully absorbed by and lodged in the skin, for long-lasting effects.

What benefits can CALECIM® Professional customers expect?

For customers with prematurely aged skin, dry or tight skin, or post-procedure skin, CALECIM® Professional Restorative Hydration Cream has been clinically proven to boost skin’s natural moisture and visibly enhance volume and firmness for a more youthful complexion and more resilient skin.

CALECIM® Professional Restorative Hydration Cream works on two fronts to combat dehydration, which is a major contributor to skin aging. While active ingredients in the CALECIM® conditioned media are allowed to penetrate deep into the skin, at the same time the cream slows down water loss through the skin by sealing the skin barrier.

When body’s natural moisture is held for longer, the result is always a more radiant appearance. Meanwhile, actives in CALECIM® conditioned media communicate on a deep cellular level, stimulating the skin to rejuvenate from within.

This double action, of protecting the skin membrane and delivering hydrating and restoring actives deep into the epidermis, is what makes CALECIM®’s newest offering the optimal hydration solution for skin.

How should CALECIM® Restorative Hydration Cream be used?

Your Restorative Hydration Cream is best when used in tandem with other CALECIM® Professional skincare products. For normal to oily skin, after cleansing and toning, apply CALECIM® Multi-Action Cream followed by CALECIM® Professional Restorative Hydration Cream. For normal to combination skin, use CALECIM® Professional Restorative Hydration Cream morning and night after cleansing, followed by sunscreen during the day. One 50ml bottle should last at least three months.

For doctors, CALECIM® Professional Restorative Hydration Cream can be incorporated into patients’ post-procedure skin care routine at home.

CALECIM® Professional Restorative Hydration Cream is now being dispensed by selected physicians in the United States, Singapore, Vietnam, and Thailand. To find out where you can purchase CALECIM® Professional products, visit CALECIM® Connect.

stem cell skin care

CALECIM® Skincare Nutrients: The LATEST Active Ingredient for Flawless Skin

For a long time now, the beauty industry has been on the lookout for new ingredients that can turn back the clock and keep skin youthful. At CALECIM®, we favor a scientific approach to skin rejuvenation. Each ingredient in CALECIM® Professional products is proven to powerfully restore skin cells. There’s no magic in the mix, although its effects may feel magical for our customers.

Below, we explain what the active ingredients found in CALECIM® Professional products are. But first, get to know the reason why our cosmeceuticals are so effective: The CALECIM® Rejuvenating Conditioned Media.

CALECIM® Cord Lining Conditioned Media for Skincare

The potency of CALECIM®’s skincare line would not be possible if not for a revolutionary breakthrough by our parent company CellResearchCorp.

Over 10 years of research, CellResearchCorp scientists discovered and patented a unique source of epithelial and mesenchymal stem cells in the cord lining membrane. The company patented the method of isolating these cells using its exclusive technology, which ensures that enormous quantities of stem cells, numbering in the billions, can be derived from this source. Using these cells, CellResearchCorp was able to develop a formula rich in skin-building proteins and nutrients. For the first time, the cosmeceutical market is able to enjoy the anti-aging, regenerative, and healing benefits of cord lining extracts through CALECIM® Professional.

This formula, which we call CALECIM® Rejuvenating Conditioned Media, carries revolutionary cell-renewing and nurturing properties. The regenerative effects of stem cells are already well known in the world of medical therapies; CALECIM® Professional is able to bring this scientifically recognized technology into the cosmeceutical world (please link ‘scientifically recognized technology to CRC website). A potent amount of the powerful CALECIM® Rejuvenating Conditioned Media goes into every CALECIM® product, ensuring maximum rejuvenating effects on both the epidermal and dermal layers of skin.

CALECIM® Rejuvenating Conditioned Media consists of these ingredients, all naturally produced by cord lining stem cells:

Collagen—A structural protein, the soluble collagen in CALECIM® Rejuvenating Conditioned Media provides strength, shape, and form to skin cells.

Albumin—This naturally occurring protein maintains osmotic pressure within cells and is required for skin turgor and fullness.

Fibronectin—A glycoprotein, the deterioration of fibronectin over time plays a major role in skin aging. Fibronectin binds to collagen, increasing its strength and supporting skin integrity.

Peptides or Glycoproteins—These amino acids are the building blocks of protein and are responsible for cellular “crosstalk”—giving skin cells the signals to restore and rebuild.

Hyaluronic Acid—Capable of holding 1000 times its own molecular weight in water, hyaluronic acid binds water and acts as a natural hydrator, helping to plump and firm skin.

These active ingredients, which are naturally produced by cord lining stem cells, are able to bind effectively to our skin, delivering unparalleled rejuvenating effects. The concentration of Rejuvenating Conditioned Media in each CALECIM® Professional product is carefully calibrated for maximum efficacy in achieving its function.

CALECIM® Professional Serum, which is used post-procedure works best to aid recovery and enhance anti-aging aesthetic effects of the procedure. CALECIM® Professional Multi-Action Cream, touted as the industry’s ‘face-lift’ in a jar, targets significant signs of aging such as loss of elasticity, skin volume, density, and facial definition. Its ‘lifting effect’, which is visible by both patients and doctors in as little time as two weeks of use, has earned its reputation as the latest miracle product in the market. CALECIM® Professional Restorative Hydration Cream, with added Aloe Vera, works very well with Hyaluronic Acid to replenish hydration levels in the skin, boosting glow and radiance that are signs of youthful, hydrated skin.

On top of the ingredients listed above, other skin-supporting ingredients are present in specific CALECIM® Professional products, including:

Tocopherol—Tocopherol, one form of Vitamin E, naturally occurs in the body but can become depleted from exposure to the sun and environment. This well-researched antioxidant protects the skin membrane from damage from free radicals.

Aloe Vera—Known as ‘the healing plant’, pure Aloe Vera is naturally high in antioxidants and has soothing, hydrating, and anti-inflammatory properties when applied to the skin.

Glyceryl Stearate—This naturally derived fatty acid forms a non-oily barrier within the skin, slowing water loss from inside out and maintaining a healthy balance of hydration in the skin.

All CALECIM® Professional cosmeceuticals are made in our ISO-certified laboratories in Singapore and dispensed exclusively through a network of physicians in CALECIM® markets. To locate a CALECIM®-authorized physician near you, please visit our Physician Directory page.


Dr. Effron on Reducing Skin Discomfort Post-Laser with CALECIM® Professional

In less than two years since its debut, CALECIM® Professional has won over patients and physicians from nearly every corner of the globe. Skincare professionals, in particular, have quickly recognized CALECIM®’s potential for alleviating pain and speeding up the healing process post in-clinic treatments. Among these is Dr. Cheryl L. Effron , a Board Certified Dermatologist and founder of the well-regarded clinic Cosmetic Dermatology of Orange County.

Dr. Effron was one of the earliest adopters of CALECIM® Professional in the United States. Having practiced dermatology for more than 38 years, her expertise runs not only to laser and chemical peels but also to skincare product development. Dr. Effron has seen more than half a million patients over the course of her career. This is exactly why it’s even more remarkable that she calls CALECIM® Professional Serum and CALECIM® Multi-Action Cream “the biggest transformation to laser procedures and aesthetic treatment protocols in my practice.”

Dr. Effron points to CALECIM®’s ability to minimize pain as one of its most potent benefits for patients receiving ablative and more intensive facial treatments. “It is clear to me that the biggest patient impedance to aesthetic laser and chemical peel treatments is the concern over pain,” she says. Dr. Effron has made CALECIM® a part of her patients’ in-clinic treatments and recovery process, with undeniable results.

She says she usually uses two CALECIM® Professional products in tandem. “CALECIM® Professional Serum, applied immediately after laser and/or chemical peels, relieves burning and stinging, making the patient immediately comfortable. CALECIM® Multi-Action Cream is then continuously used post-procedure to repair and enhance fine line improvement and pigment balance.”

Recently Dr. Effron conducted a split-face clinical trial to evaluate the effectiveness of CALECIM® Professional in reducing warmth, redness, and pain after fractional CO2 laser resurfacing. During the trial, 14 patients reported on their recovery process over the course of 30 days. The study concluded that the skin treated with CALECIM® Professional Serum demonstrated greater comfort post-laser resurfacing in terms of all three criteria.

Perhaps most telling, Dr. Effron says, “All patients described a general increase in ‘overall comfort’ and expressed a wish to obtain CALECIM® Professional Serum for routine use on their facial skin.”

Dr. Effron is so convinced of the revolutionary benefits of CALECIM® Professional she has lectured and given seminars on the effects she’s observed in her own practice. She says ultimately the results speak for themselves.

“When I discuss my findings with other dermatologists, they are excited about the prospect of introducing CALECIM® Professional products to their practice,” she says. “The success of the products is evident in the patient’s’ desire for continuous use of the CALECIM® Multi-Action Cream.”

To learn more about how you can gain access to CALECIM® Professional Serum, Multi-Action Cream, or Restorative Hydrating Cream, visit CALECIM® Connect.


Stem Cell Science that Exceeds the Skincare Standard

“It is no exaggeration to say that the technology behind CALECIM® Professional is as game-changing as Apple was to personal computing and Facebook was to social media.”—CALECIM® Professional CEO, Gavin Tan

Real Science. Beauty + Innovation. Meet CALECIM® Professional.

CALECIM® Professional is a revolutionary product that encourages skin to regain its youthfulness based on our deep understanding of stem cell technology. Clinical results from across the globe illustrate exceptionally fast, thorough, and effective transformation in the appearance of aging skin. Dermatologists, medical aestheticians, and skincare experts—from Asia to the States—are now integrating our serum and cream into their in-clinic treatment procedures (both ablative and non-ablative) to quickly assist reduction in swelling and redness, thus improving post procedure discomfort and promoting long-term skin cell turnover and rejuvenation with extended at-home use.

CALECIM® Professional Skincare products are composed of a patented protein mix derived from umbilical cord lining extract. Creating the perfect media for skin health, this extract consists of the full complement of proteins such as hyaluronic acid, fibronectin, glycoproteins and peptides which are naturally generated by umbilical cord lining cells.

Patented Stem Cell Science Derived from Wound Healing

We are, in fact, a result of our parent organization, CellResearch Corp (CRC), a biotech company known internationally for its intensive research into therapies using umbilical cord lining stem cells with an expertise in wound healing. CellResearch Corp is the only company in the world with multiple patents for stem cell technology derived from the umbilical cord lining which is now on clinical trial in a USFDA study to treat chronic diabetic wounds. Cord Lining Stem Cells are also licensed to be banked by cord blood banks around the world. Other studies are ongoing to develop therapies for diseases affecting the brain, heart, cornea, and skin using cord lining stem cells as the treatment platform.

A Paradigm Shift in Medical Science and Now Skincare

CALECIM® Professional boasts unique access to CellResearch Corporation’s powerful, unparalleled, patented stem cell technology and now, we are pleased to introduce to medical aesthetic practices in America, our translation of this science into physician-dispensed skincare.

CALECIM® Professional effectively combats aging, boosts the skin’s regenerative process, and supports overall skin health. CALECIM® does this by using the very same groundbreaking stem cell technology that medical scientists around the world are exploring to treat a myriad of diseases

Through clinical trials and partnerships with dermatologists, medical professionals and their patients worldwide, it has been observed that topical application of CALECIM® Professional products to the face stimulates the shedding of old cells and the proliferation of new cells, returning skin cell turnover from 40 days back to 28 days. The results are dramatic and visible within 14 days of use. See results.

CALECIM® Professional has multiple benefits. It is been observed to:

  • Reduce pigmentation
  • Restore skin fullness and elasticity
  • Enhance facial definition
  • Dramatically decrease fine lines
  • And very importantly, we have observed that it substantially reduces redness and inflammation of the skin after in-clinic procedures

What is the Core Technology from which CALECIM® Professional Is Drawn?

Our scientists discovered that the lining of the umbilical cord—traditionally regarded to be medical waste—contains the richest source of Epithelial and Mesenchymal stem cells which can be ethically derived without injury to mother or infant. This stem cell source produces billions of stem cells which secrete proteins responsible for cell regeneration and repair. The stem cells are neonatal, meaning that they are more powerful and robust compared to adult stem cells.

To create our formula, we draw on CellResearch Corporation’s technology which uses the extracts of umbilical cord lining. Nutrients, collagen, peptides and other proteins are secreted by umbilical cord lining stem into cell culture media which is collected to produce CALECIM®. CALECIM® works miracles through this ‘youth-giving broth’ without the use of the cells themselves.

In essence, CALECIM® is able to create the perfect environment for our own skin to reproduce essential nutrients needed for a healthy appearance. Laboratory observations show that skin is able to regenerate faster, develop denser epidermal layers and heal faster when exposed to CALECIM®.All in all, behaving as young, healthy skin should.

How to Access CALECIM® Professional

CALECIM® Professional is available through select dermatologists, plastic surgeons, and medical aesthetic clinics. Patients are also able to access the home-care regime through CALECIM® Connect, a portal that directly links patients to doctors’ unique e-boutique for direct purchase from their own physicians.

To learn more about CALECIM® Professional or to speak with a representative, please visit CALECIM® Connect.

nd:yag laser

Getting the Most Out of Your Laser Treatment

Pair Nd:YAG Laser + CALECIM® Professional

There was a time when topical products had little importance in the treatment room. Patients paid to receive treatments, and any post-procedure measures were considered secondary — simply add-ons to finish up the main event. These days, physicians know that there is an opportunity to enhance in-clinic treatments immediately after the procedure, as skin in recovery mode is in a prime position to absorb nutrients. Topical products, especially those with effective active ingredients, now play a bigger role in treatment protocols.

Among the most recent breakthroughs in post-procedure advanced skin care is the line of CALECIM® Professional cosmeceuticals. CALECIM® Professional products contain a protein-rich Rejuvenating Conditioned Media derived from umbilical cord lining extract. This formula creates a very powerful healing and rejuvenating environment for skin of any age. When used in conjunction with the Nd:YAG laser, CALECIM® Professional Serum boosts skin healing and the aesthetic results, adding more value and giving more comfort to the patients.

Here’s how it works:

CALECIM® Professional Complements Nd:YAG Laser

One of the handiest lasers in the skin physician’s arsenal is the Nd:YAG, which is able to penetrate deep into the skin. It’s well absorbed by hemoglobin and melanin chromophores, making it particularly effective for treating facial veins, pigmentation, and discoloration. The Nd:YAG laser is also able to heat skin tissue in a non-ablative manner to stimulate new collagen growth while resurfacing the skin and improving moderate wrinkles.

After Nd:YAG, or any controlled trauma to the skin tissue, physicians have applied CALECIM® Professional Serum in-clinic to immediately soothe the skin and boost the body’s natural healing process. To further optimize the results of their procedure, patients should use CALECIM® Professional Multi-action Cream at home in the days that follow to enhance their results.

CALECIM® Professional has already proven its ability to restore epidermal cell turnover time in clinical trials. The line is quickly becoming the physicians’ post-treatment serum of choice due to its undeniable, fast-acting properties. The secret of its effectiveness lies in the cord lining stem cell technology, discovered and patented by CALECIM® Cosmeceuticals’ parent company, CellResearchCorp.

Applying Stem Cell Science to Skin Care

CellResearchCorp has harnessed more than a decade’s experience in cord lining stem cell knowledge and technology to develop CALECIM® Professional cosmeceuticals. Each CALECIM® Professional product has a specified concentration of Rejuvenating Conditioned Media, which contains active stem cell-derived power-proteins and growth factors.

CALECIM® Rejuvenating Conditioned Media is derived from mammalian neonatal umbilical cord lining stem cells. The proteins from these cells are more powerful than those from adult stem cells, and can easily communicate with skin cells in the human body, effectively directing them to repair and regenerate. Hence, they function as youth-messengers, basically telling the skin to act younger.

Boosting The Skin’s Healing Response

The goal of ‘controlled trauma’ procedures is to stimulate the skin into its regenerative cycle, where it responds to the ‘injury’ by actively repairing itself. However, the more we age the fewer regenerative signals our stem cells are able to send. This is why skin doesn’t heal as well or as fast as it once did, whether after normal wounds or after treatments such as Nd:YAG Laser ablation. This is where CALECIM® Professional can help.

By recreating the healing environment of much younger skin, injured skin cells are given stronger signals to repair quickly and effectively. CALECIM® Professional Serum contains a staggering 80% concentration of CALECIM® Rejuvenating Conditioned Media. The active power-proteins in the media communicate instantly with skin cells to jumpstart the healing response, leading to decreased downtime, and more importantly, improved results from the procedure. This is what makes CALECIM® Professional an essential aid for physicians and a synergistic complement to laser treatments such as Nd:YAG.

Using CALECIM® Professional After Nd:YAG Procedure

For treatments using Nd:YAG lasers 532nm and 1064nm wavelengths, CALECIM® Professional Serum should be applied in sequence to each facial aesthetic zone to ensure uniform coverage. Gently massage the full quantity of serum from one ampoule into the skin using small circular motions until it is fully absorbed. For at-home maintenance, the recommended post-procedure standard of care is two ampoules of CALECIM® Professional Serum to be used over the course of four consecutive mornings and nights after a mild cleanser, before applying CALECIM® Multi-Action Cream over the treated area, followed by CALECIM® Restorative Hydration Cream to reduce trans-epidermal water loss.